1/16/2024 0 Comments Phoenix winnonlin version 64The baseline of ALT and free IL-6 were found associated with PK/PD parameters during covariates exploration. CRP as the fast-decreasing endpoint and DAS28 as the slow-reacting endpoint were both fitted well through an indirect response model. Apparent systemic clearance was 0.015 L/h, central volume was 8.04 L. A two-compartment model with a sequential zero-first order absorption and a first order elimination best described PK behavior of WBP216. Non-linear mixed effects modeling was used for a population PK/PD analysis. PK, CRP and DAS28 data of WBP216 were collected from 26 RA patients in a single ascending dose study. To optimize the dosage regimen for future clinical trials, pharmacokinetics (PK) and pharmacodynamics (PD) of WBP216 would be firstly characterized in Chinese rheumatoid arthritis (RA) patients. WBP216 is an innovative IL-6 antibody, presenting high affinity to IL-6 and a long half-life (40–60 days).
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